THE USE OF A CHLORAL HYDRATE FORMALDEHYDE FIXATIVE SOLUTION IN ENZYME HISTOCHEMISTRY

Chloral and Chloral Hydrate

These substances were considered by a previous Working Group, in February 1995 (IARC, 1995). Since that time, new data have become available and these have been incorporated into the monograph and taken into consideration in the present evaluation.

Chloral and Chloral Hydrate

Chloral hydrate

Major uses Chloral hydrate (synthesized in 1832 and introduced into medicine 1869) is the oldest member of sedative-hypnotic drugs. To the same group belong paraldehyde, bromide, urethane, and sulfonal. Metabolite of chloral hydrate, trichloroethanol, is also an excellent hypnotic agent, but is not often used as such due to its physical and irritant properties. At present, chloral hydrate is la...

Hydrate of Chloral in Tetanus

"With reference to treatment, it will be noticed that ot the 83 cases, two absconded from the hospital, so that, practically, we have to deal with 81 instances of tetanus, and of these 13 are stated as having been " relieved" when discharged from hospital; this is doubtless a very unsatisfactory way of accounting for cases of tetanus, but it is unavoidable in this country ; the friends of the p...

Toxicology of chloral hydrate in the mouse.

Chloral hydrate has been found in our drinking water supplies at levels up to 5 micrograms/1. The purpose of this study was to evalute the acute and subchronic toxicology of chloral hydrate in the random-bred CD-1 mouse, to provide data for risk assessment. The acute oral LD50 of this compound was 1442 and 1265 mg/kg in male and female mice, respectively. Acute toxicity appeared to be related t...